Comparative Analysis of Renal Impairment in Positive and Negative HIV-Individuals at Kono Government Hospital, Sierra Leone

Authors

  • Arthur B C Garber College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone and Ministry of Health, Government of Sierra Leone, Koinadugu College, Kabala, Sierra Leone
  • Saidu Bangura College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone and Ministry of Health, Government of Sierra Leone, Koinadugu College, Kabala, Sierra Leone
  • Angie Pinto Partners in Health Sierra Leone
  • Musa Bangura Partners in Health Sierra Leone
  • Hamzza Kamara College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone and Ministry of Health, Government of Sierra Leone, Koinadugu College, Kabala, Sierra Leone
  • Esther Blessing Thomas College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone and Ministry of Health, Government of Sierra Leone, Koinadugu College, Kabala, Sierra Leone
  • Sorie I O Bangura University of Sierra Leone Teaching Complex, Connaught Hospital Department of Microbiology
  • Sahr Kanawa Kono Government Hospital
  • Isatta Wurie College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone and Ministry of Health, Government of Sierra Leone, Koinadugu College, Kabala, Sierra Leone
  • Mohamed Conteh College of Medicine and Allied Health Sciences, University of Sierra Leone, Freetown, Sierra Leone and Ministry of Health, Government of Sierra Leone, Koinadugu College, Kabala, Sierra Leone
  • Atiba Adeniran Samuel

DOI:

https://doi.org/10.4314.1.2.11

Abstract

Background: Non-communicable disease is of major concern affecting a significant portion of the global population, furthermore renal impairment is of great concern and has affected so many lives. It is a serious and gradual condition marked by the progressive deterioration of kidney function. In recent years, Renal impairment has emerged as a clinically relevant and significant issue. The aim of this study was to compare analysis of renal impairment in individuals with HIV, diabetes, and hypertension.

Methods: This was a cross-section quantitative study. It was conducted from June to September 2024. A total of Two Hundred and Seventy-Five (275) participants were selected using a consecutive sampling technique. Serum creatinine and CD4 counts were measured in HIV-positive individuals, and the eGFR was calculated using the CKD-Epi 2021 formula. Data analysis was done using SPSS version 16.

Results: Among the study population, 158 participants (57.5%) were HIV-positive, while 62 (39.2%) and 55 (34.8%) were HIV-negative individuals diagnosed with hypertension and diabetes, respectively. The overall prevalence of renal impairment was found to be 34.2% (n = 54) among HIV-positive individuals, 30.6% (n = 19) among hypertensive participants, and 38.2% (n = 21) among those with diabetes. Participants aged 31–40 years demonstrated a significantly higher likelihood of renal impairment (adjusted odds ratio [aOR] = 5.37; 95% CI: 2.414–12.489), as did those over 50 years (aOR = 4.93; 95% CI: 1.491–16.351). Among diabetic participants, older age was also significantly associated with renal impairment (aOR = 6.379; 95% CI: 1.129–36.060). Furthermore, hypertensive females were identified as having an increased risk of developing renal impairment.

Conclusion: The prevalence of renal impairment was notably high among the study participants. Increased age was linked to renal impairment, and also females within the hypertensive group.

Keywords: Renal Impairment, Diabetes, HIV-AIDS, Hypertension, eGFR.

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Published

2026-05-21

Issue

Vol. 16 No. 2 (2025): December 2025

Section

Original Articles

License

Submission of manuscripts to the Sierra Leone Journal of Biomedical Research is of the understanding that the article either in part or whole is not under consideration for publication in any other Journal. Accepted papers become the permanent property of Sierra Leone Journal of Biomedical Research but unrestricted use, distribution, and reproduction in any medium is permitted, provided the original work is properly cited.